A comparison of adding liraglutide versus a single daily dose of insulin aspart to insulin degludec in subjects with type 2 diabetes (BEGIN: VICTOZA ADD-ON).

@article{Mathieu2014ACO,
  title={A comparison of adding liraglutide versus a single daily dose of insulin aspart to insulin degludec in subjects with type 2 diabetes (BEGIN: VICTOZA ADD-ON).},
  author={Chantal Mathieu and Helena W Rodbard and Bertrand Cariou and Yehuda Handelsman and Athena Philis-Tsimikas and Ann Marie Ocampo Francisco and Azhar N Rana and Bernard Zinman},
  journal={Diabetes, obesity & metabolism},
  year={2014},
  volume={16 7},
  pages={636-44}
}
AIM Two treatment strategies were compared in patients with type 2 diabetes (T2DM) on basal insulin requiring intensification: addition of once-daily (OD) liraglutide (Lira) or OD insulin aspart (IAsp) with largest meal. METHODS Subjects completing 104 weeks (52-week main trial BEGIN ONCE-LONG + 52-week extension) on insulin degludec (IDeg) OD + metformin with HbA1c ≥ 7.0% (≥53 mmol/mol) were randomized to IDeg+Lira [n = 88, mean HbA1c: 7.7% (61 mmol/mol)] or IDeg+IAsp (n = 89, mean HbA1c: 7… CONTINUE READING
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