A comparison of DNA binding profiles of dinuclear platinum compounds with polyamine linkers and the trinuclear platinum phase II clinical agent BBR3464

@article{McGregor2001ACO,
  title={A comparison of DNA binding profiles of dinuclear platinum compounds with polyamine linkers and the trinuclear platinum phase II clinical agent BBR3464},
  author={Tracey D. McGregor and Alexander Hegmans and Jana Kasparkova and Kamila Neplechov{\'a} and Olga N. Novakova and Hana Peňazov{\'a} and Oldřich Vr{\'a}na and Viktor Brabec and Nicholas Farrell},
  journal={JBIC Journal of Biological Inorganic Chemistry},
  year={2001},
  volume={7},
  pages={397-404}
}
The DNA binding profiles of three bis Pt(II) polyamine-linked compounds, [{trans-PtCl(NH3)2}2{µ-spermine-N 1,N 12}]4+, [{trans-PtCl(NH3)2}2{µ-spermidine-N 1,N 8}]3+, and [{trans-PtCl(NH3)2}2{µ-BOC-spermidine}]2+, were compared with that of a novel trinuclear phase II clinical agent, [{trans-PtCl(NH3)2}2{µ-trans-Pt(NH3)2(H2N(CH2)6NH2)2}]4+. All of the compounds bind preferentially in a bifunctional manner, according to unwinding of supercoiled DNA circles. The kinetics of binding of these… CONTINUE READING
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