A comparison of AT1 angiotensin II antagonists at pre- and postjunctional angiotensin II receptors of the rat tail artery

@article{Pinheiro2002ACO,
  title={A comparison of AT1 angiotensin II antagonists at pre- and postjunctional angiotensin II receptors of the rat tail artery},
  author={H{\'e}lder Pinheiro and Daniel Moura and Ant{\'o}nio Albino-Teixeira and Claudia Durand Alves and Leonid Torres and Serafim Guimar{\~a}es},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={2002},
  volume={366},
  pages={537-542}
}
A comparison was made of the influence of candesartan, ZD7155, losartan and eprosartan on angiotensin II effects at pre- and postjunctional AT1 receptors of the rat tail artery. To study the anti-angiotensin II effect at prejunctional receptors, the tissues were preincubated with [3H]noradrenaline and then superfused and electrically stimulated (1 Hz, 2 ms, 50 mA, during 5 min); to study the angiotensin II effect at postjunctional receptors, non-cumulative concentration-response curves to… CONTINUE READING