A comparison of 1-benzylpiperazine and methamphetamine in their acute effects on anxiety-related behavior of hooded rats.

@article{Herbert2009ACO,
  title={A comparison of 1-benzylpiperazine and methamphetamine in their acute effects on anxiety-related behavior of hooded rats.},
  author={Cherie E Herbert and Robert N. Hughes},
  journal={Pharmacology, biochemistry, and behavior},
  year={2009},
  volume={92 2},
  pages={243-50}
}
Following i.p. treatment with saline, 10 or 20 mg/kg 1-benzylpiperazine, or 1 or 2 mg/kg methamphetamine, hooded rats were observed in an open field, a light-dark box and (24 h after exposure to the drugs) a Y maze with one novel and one familiar arm. Both drugs increased open-field rearing and ambulation, but only methamphetamine increased and decreased respectively occupancy of center squares and corners, while stereotyped head movements were increased by 20 mg/kg benzylpiperazine. Time spent… CONTINUE READING