A comparison between the negative inotropic action of various antiarrhythmic drugs and their influence on calcium movements in heart muscle.

@article{Graa1972ACB,
  title={A comparison between the negative inotropic action of various antiarrhythmic drugs and their influence on calcium movements in heart muscle.},
  author={A S Graça and Pieter A. van Zwieten},
  journal={The Journal of pharmacy and pharmacology},
  year={1972},
  volume={24 5},
  pages={
          367-73
        }
}
The influence of quinidine, lidocaine, (+)- and (±)-propranolol, l-(+)- and d-(–)-INPEA and (±)-alprenolol on contractile force and transmembraneous calcium exchange was studied in beating guinea-pig atria (3Hz) and in resting left auricles. Quinidine and lidocaine (5 × 10−5m) reduced the contractile force by approximately 34 and 19%, respectively. Both drugs diminished the Ca2+ flux during excitation without affecting the exchangeable fraction at equilibrium or the total Ca2+ content. In… CONTINUE READING