A comparison between bispectral index analysis and auditory-evoked potentials for monitoring the time to peak effect to calculate the plasma effect site equilibration rate constant of propofol.

@article{Zhang2007ACB,
  title={A comparison between bispectral index analysis and auditory-evoked potentials for monitoring the time to peak effect to calculate the plasma effect site equilibration rate constant of propofol.},
  author={M-Z Zhang and Qinfen Yu and Yining Huang and Shufang Wang and Xiaolin. Wang},
  journal={European journal of anaesthesiology},
  year={2007},
  volume={24 10},
  pages={
          876-81
        }
}
BACKGROUND AND OBJECTIVES To the best of our knowledge, the value of the plasma effect site equilibration rate constant (k(e0)) of propofol has not been reported in Chinese patients. The aim of this prospective, randomized study was to examine the characteristics of the time to peak effect (T(PEAK)) of propofol, a pharmacokinetic-independent descriptor of blood-brain equilibration, and k(e0) derived from T(PEAK) with A-line auditory-evoked potential monitor and Aspect A-2000 bispectral index… CONTINUE READING

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