A comparative voltage and current-clamp analysis of feedback and feedforward synaptic transmission in the striatal microcircuit in vitro.

@article{Gustafson2006ACV,
  title={A comparative voltage and current-clamp analysis of feedback and feedforward synaptic transmission in the striatal microcircuit in vitro.},
  author={Nicholas Gustafson and Elakkat Gireesh-Dharmaraj and Uwe Czubayko and Kim T. Blackwell and Dietmar Plenz},
  journal={Journal of neurophysiology},
  year={2006},
  volume={95 2},
  pages={737-52}
}
Striatal spiny projection (SP) neurons control movement initiation by integrating cortical inputs and inhibiting basal ganglia outputs. Central to this control lies a "microcircuit" that consists of a feedback pathway formed by axon collaterals between GABAergic SP neurons and a feedforward pathway from fast spiking (FS) GABAergic interneurons to SP neurons. Here, somatically evoked postsynaptic potentials (PSPs) and currents (PSCs) were compared for both pathways with dual whole cell patch… CONTINUE READING
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