A comparative view on sex determination in medaka

  title={A comparative view on sex determination in medaka},
  author={Manfred Schartl},
  journal={Mechanisms of Development},
  • M. Schartl
  • Published 1 July 2004
  • Biology
  • Mechanisms of Development

Figures from this paper

Molecular analysis of the sex-determining region of the platyfish Xiphophorus maculatus.

The sex determination region of the platyfish is very instable and frequently undergoes duplications, deletions, and transpositions, which might be linked to the high genetic variability affecting sex determination and other sex-linked traits in Xiphophorus.

A Syntenic Region Conserved from Fish to Mammalian X Chromosome

A syntenic segment within this region that is well conserved in several teleosts was shown to be present in mammalian X chromosomes, suggesting a common ancestral origin of vertebrate sex chromosomes.

Sex Chromosome Evolution in Lizards: Independent Origins and Rapid Transitions

It is suggested that lizard sex determination may be much more the result of an interplay between sex chromosomes and temperature than previously thought, such that the sex determination mode is influenced by the nature of heterogamety as well as temperature sensitivity and the stage of sex chromosome degeneration.

DMY gene induces male development in genetically female (XX) medaka fish

It is demonstrated that a 117-kb genomic DNA fragment that carries DMY is able to induce testis differentiation and subsequent male development in XX (genetically female) medaka and suggested that the functional difference between the X and Y chromosomes in medaka is a single gene.

Sex Chromosome Evolution in a Hermaphrodite

This thesis aims at producing a deeper understanding of the very beginning of sex chromosome evolution in a hermaphrodite ancestor, and shows evidence of a genetically-based trade-off in the sex-limited experimental evolution, indicating that it might have reinforced a negative intersexual genetic correlation between sex roles during the course of the experiment.

Sex Chromosome Conservation, DMRT1 Phylogeny and Gonad Morphology in Diploid Palearctic Green Toads (Bufo viridis Subgroup)

3 cross-amplifying sex-linked microsatellite markers are used to uncover sex determination systems and sex chromosomes in purebred, diploid Palearctic green toads (Bufo viridis subgroup), which had so far only been characterized in laboratory-bred hybrids, and support an XY system in B. viridis and B. variabilis.

Sex Determination in the Squalius alburnoides Complex: An Initial Characterization of Sex Cascade Elements in the Context of a Hybrid Polyploid Genome

The contribution of these genes to gonad integrity maintenance and functionality is apparently unaltered in the hybrids, suggesting that no abrupt shifts in gene expression occurred as a result of hybridisation.

Governing Sex Determination in Fish: Regulatory Putsches and Ephemeral Dictators

The identification of new sex-determining genes in Oryzias latipes and medaka will shed new light on the exceptional evolutionary instability governing sex determination in fish.

Fish Gonadogenesis. Part I: Genetic and Environmental Mechanisms of Sex Determination

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Absence of the Candidate Male Sex-Determining Gene dmrt1b(Y) of Medaka from Other Fish Species

Variability of genetic sex determination in poeciliid fishes

It is proposed that the high plasticity of the sex-determining region might explain the variability of sex determination in Xiphophorus and other poeciliids.

Identification of the sex chromosomes of the medaka, Oryzias latipes, by fluorescence in situ hybridization

In the medaka, Oryzias latipes, which does not have cytologically recognizable sex chromosomes, the sex is genetically determined and the mechanism of sex determination (XX/XY) can be revealed by

A duplicated copy of DMRT1 in the sex-determining region of the Y chromosome of the medaka, Oryzias latipes

  • I. NandaM. Kondo M. Schartl
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 2002
It is found that in the fish medaka the Y chromosome-specific region spans only about 280 kb and contains a duplicated copy of the autosomal DMRT1 gene, named D MRT1Y, which is the only functional gene in this chromosome segment and maps precisely to the male sex-determining locus.

Molecular-cytogenetic analysis reveals sequence differences between the sex chromosomes of Oreochromis niloticus: evidence for an early stage of sex-chromosome differentiation

It is shown that chromosome microdissection and subsequent amplification by degenerate oligonucleotide-primed PCR (DOP-PCR) can be used to produce in situ hybridization probes to this largest pair of O. niloticus chromosomes, providing further support for the theory that this chromosome pair is related to sex determination and suggests that the sex chromosomes are at a very early stage of divergence.

Differences in recombination frequencies during female and male meioses of the sex chromosomes of the medaka, Oryzias latipes.

The hypothesis that the heterogeneous sex chromosomes in the medaka were derived from suppression of recombination between autosomal chromosomes is supported.

Common spontaneous sex-reversed XX males of the medaka Oryzias latipes.

The screening of strains of Northern and Southern medaka indicated that the candidate male sex-determining gene dmrt1bY may not be necessary for male development in every case, but that its function can be taken over by so far unidentified autosomal modifiers.

DMY is a Y-specific DM-domain gene required for male development in the medaka fish

Rec recombinant breakpoint analysis is used to restrict the sex-determining region in medaka fish to a 530-kilobase stretch of the Y chromosome, and it is suggested that thesex-specific DMY is required for testicular development and is a prime candidate for the medaka sex-Determining gene.

A New Look at Sex Determination in Poeciliid Fishes

Of particular interest to geneticists are several cases of atypical sex determination in mammals, including humans, in which an autosomal gene causes the testicular differentiation of XX individuals, which has raised the question as to the location of the male-determining gene.