A comparative trial of amitriptyline and zimelidine in post-herpetic neuralgia

@article{Watson1985ACT,
  title={A comparative trial of amitriptyline and zimelidine in post-herpetic neuralgia},
  author={C. Peter N. Watson and R. J. Evans},
  journal={Pain},
  year={1985},
  volume={23},
  pages={387-394}
}
Serotoninergic pathways are believed to be important in pain mechanisms. Accordingly, we studied the action of zimelidine, a very highly serotoninergic antidepressant, in relieving the pain of post-herpetic neuralgia. Fifteen patients received zimelidine and amitriptyline in that order in an open-label cross-over study. Only one patient with zimelidine obtained a good result, whereas 8 patients on amitriptyline amitriptyline has a pain-relieving action, at least in post-herpetic neuralgia… CONTINUE READING
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