A comparative trial of amitriptyline and zimelidine in post-herpetic neuralgia

  title={A comparative trial of amitriptyline and zimelidine in post-herpetic neuralgia},
  author={C Peter N Watson and R. Evans},
  • C Peter N Watson, R. Evans
  • Published 1985
  • Medicine
  • Pain
  • Serotoninergic pathways are believed to be important in pain mechanisms. Accordingly, we studied the action of zimelidine, a very highly serotoninergic antidepressant, in relieving the pain of post-herpetic neuralgia. Fifteen patients received zimelidine and amitriptyline in that order in an open-label cross-over study. Only one patient with zimelidine obtained a good result, whereas 8 patients on amitriptyline amitriptyline has a pain-relieving action, at least in post-herpetic neuralgia… CONTINUE READING
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