A comparative transcriptomic analysis reveals conserved features of stem cell pluripotency in planarians and mammals.

@article{Labb2012ACT,
  title={A comparative transcriptomic analysis reveals conserved features of stem cell pluripotency in planarians and mammals.},
  author={Roselyne M Labb{\'e} and Manuel Irimia and Ko W. Currie and Alexander Lin and Shu Jun Zhu and David R Brown and Eric Ross and V{\'e}ronique Voisin and Gary D. Bader and Benjamin J. Blencowe and Bret J Pearson},
  journal={Stem cells},
  year={2012},
  volume={30 8},
  pages={1734-45}
}
Many long-lived species of animals require the function of adult stem cells throughout their lives. However, the transcriptomes of stem cells in invertebrates and vertebrates have not been compared, and consequently, ancestral regulatory circuits that control stem cell populations remain poorly defined. In this study, we have used data from high-throughput RNA sequencing to compare the transcriptomes of pluripotent adult stem cells from planarians with the transcriptomes of human and mouse… CONTINUE READING