Corpus ID: 40259393

A comparative study on the radiosensitizing effects and cytotoxic properties of misonidazole and 2,4-dinitroimidazole-1-ethanol in HeLa S3 cells.

@article{Murayama1982ACS,
  title={A comparative study on the radiosensitizing effects and cytotoxic properties of misonidazole and 2,4-dinitroimidazole-1-ethanol in HeLa S3 cells.},
  author={C. Murayama and H. Hori and S. Inayama and T. Mori},
  journal={Gan},
  year={1982},
  volume={73 4},
  pages={
          588-91
        }
}
Hypoxic HeLa S3 cells were used to compare the radiosensitizing and cytotoxic properties of misonidazole and 2,4-dinitroimidazole-1-ethanol. To achieve an enhancement ratio of 1.6 (C1.6), the required concentrations of 2,4-dinitroimidazole-1-ethanol and misonidazole were 0.15 and 2.4mM, respectively; at this ratio, the cytotoxicity values (1/To) of the two compounds were 0.054 hr-1 and 0.29 hr-1. These findings indicate that 2,4-dinitroimidazole-1-ethanol had a greater sensitizing effect at… Expand
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