A comparative study on the effects of tetracyclines and lithium on the cyclic amp second messenger system in rat brain

  title={A comparative study on the effects of tetracyclines and lithium on the cyclic amp second messenger system in rat brain},
  author={Arne M{\o}rk and Arne Geisler},
  journal={Progress in Neuro-Psychopharmacology and Biological Psychiatry},
  • A. Mørk, A. Geisler
  • Published 31 January 1995
  • Biology, Chemistry
  • Progress in Neuro-Psychopharmacology and Biological Psychiatry
cAMP induction by ouabain promotes endothelin-1 secretion via MAPK/ERK signaling in beating rabbit atria
  • Li-qun Peng, Ping Li, B. Cui
  • Biology, Medicine
    The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology
  • 2016
It is demonstrated that ouabain increases atrial cAMP levels and promotes atrial ET-1 secretion via the mitogen-activated protein kinase (MAPK)/ERK signaling pathway, which may explain the development of cardiac hypertrophy in response to digitalis-like compounds.
Development of lithium-induced nephrogenic diabetes insipidus is dissociated from adenylyl cyclase activity.
The first proper cell model to study lithium-induced NDI was developed and it was demonstrated that the lithium- induced downregulation of AQP2 and development of NDI occur independent of adenylyl cyclase activity in vitro and in vivo.
Influence of Platelet Aggregation Modulators on Cyclic AMP Production in Human Thrombocytes
Wortmannin, quercetin, ouabain and amiloride increase cyclic AMP level in human platelets, which shows a synergetic interference of lactoferrin in signal pathways along with phosphatidylinositol 3-kinase and control over protein kinases.
Behavioural effects of NKH-477, a forskolin analogue, on locomotion and rearing in rats.
The interaction between NKH-477 and lithium suggests that the well-documented ability of lithium to inhibit stimulation of the cAMP system is relevant to its behavioural effects; however, the transient nature of this interaction, suggests that other biochemical mechanisms are involved in the behavioural effects of lithium.
Ouabain-induced stimulation of sodium-hydrogen exchange in rat optic nerve astrocytes.
Results are consistent with increased capacitative calcium entry and subsequent cAMP-PKA-dependent stimulation of NHE1 in ouabain-treated cells.
The mechanisms of aquaporin control in the renal collecting duct.
Water channels (AQP2 and 3) of principal cells are regulated at the level of expression (long term regulation) and the current knowledge on the molecular mechanisms underlying the short and long term regulation of water channels in principal cells is summarized.
exchange in rat optic nerve astrocytes Ouabain-induced stimulation of sodium-hydrogen
This paper presents evidence for the presence of NHE1 and NHE2 isoforms and regulation by arginine vasopressin Cerebral microvascular endothelial cell Na/H exchange through a sodium/hydrogen exchanger-1 in rat optic nerve.
The molecular basis of nephrogenic diabetes insipidus
The progress with regard to the molecular basis of antidiuresis contributes to the understanding of acquired forms of NDI on a molecular level and all gene-therapeutic approaches lack safety and efficiency.
The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals : 131. Lithium and lithium compounds
This document aims at establishing dose-response/dose-effect relationships and defining a critical effect based only on the scientific literature, not to give a numerical occupational exposure limit value.


Effects of lithium on calmodulin-stimulated adenylate cyclase activity in cortical membranes from rat brain.
The present results suggest that lithium might influence the interaction of calmodulin with the enzyme and/or interfere with the divalent cation site(s) on the adenylate cyclase system.
Calmodulin-dependent adenylate cyclase activity in rat cerebral cortex: effects of divalent cations, forskolin and isoprenaline.
It is demonstrated that Ca2+ -CaM potentiates beta-adrenergic adenylate cyclase activity and thus is able to modulate neurotransmitter stimulation in cortex and thus can be restored by addition of exogenous CaM.
Effects of lithium and rolipram enantiomers on locomotor activity in inbred mice.
  • D. Smith
  • Psychology, Biology
    Pharmacology & toxicology
  • 1990
The behavioural findings are consistent with the opposite pharmacological effects of lithium and rolipram on cAMP, and support the notion that cAMP availability in brain may play a role in behavioural effects of the drugs.