A comparative study on invasion, survival, modulation of oxidative burst, and nitric oxide responses of macrophages (HD11), and systemic infection in chickens by prevalent poultry Salmonella serovars.

@article{He2012ACS,
  title={A comparative study on invasion, survival, modulation of oxidative burst, and nitric oxide responses of macrophages (HD11), and systemic infection in chickens by prevalent poultry Salmonella serovars.},
  author={Haiqi He and Kenneth J. Genovese and Christina L. Swaggerty and David J. Nisbet and Michael H. Kogut},
  journal={Foodborne pathogens and disease},
  year={2012},
  volume={9 12},
  pages={
          1104-10
        }
}
Poultry is a major reservoir for foodborne Salmonella serovars. Salmonella Typhimurium, Salmonella Enteritidis, Salmonella Heidelberg, Salmonella Kentucky, and Salmonella Senftenberg are the most prevalent serovars in U.S. poultry. Information concerning the interactions between different Salmonella species and host cells in poultry is lacking. In the present study, the above mentioned Salmonella serovars were examined for invasion, intracellular survival, and their ability to modulate… 
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Background Citations
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Methods Citations
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Results Citations
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50 Citations

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Citation Type

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Results indicate that although antibacterial factors contribute to the clearance of invading Salmonella, some of the differences in response could also be due to the different virulence properties of these serovars.
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Nitric Oxide as a Biomarker of Intracellular Salmonella Viability and Identification of the Bacteriostatic Activity of Protein Kinase A Inhibitor H-89
TLDR
H-89 has bacteriostatic activity against Salmonella, independent of host cell protein kinase A or Akt1 activity, which demonstrates that NO-based screening using S. Enteritidis-infected HD11 cells is a viable tool to identify chemicals with anti-intracellular Salmoneella activity.
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