A comparative study of top-down and bottom-up approaches for the preparation of micro/nanosuspensions.

  title={A comparative study of top-down and bottom-up approaches for the preparation of micro/nanosuspensions.},
  author={Sudhir Verma and Rajeev Gokhale and Diane J. Burgess},
  journal={International journal of pharmaceutics},
  volume={380 1-2},
Nano-sizing offers a promising method for the formulation of poorly aqueous soluble compounds. Nanosuspensions can be prepared by top-down or bottom-up approaches. The different conditions encountered in these two approaches can greatly affect nanosuspension characteristics. In this study, milling via microfluidization and precipitation via sonication were compared to study their effects on the formation and stability of ibuprofen nanosuspensions. Various stabilizers (SLS, PVP K-30, Pluronic F… CONTINUE READING
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