A comparative study of the protein C pathway in septic and nonseptic patients with organ failure.

@article{Borgel2007ACS,
  title={A comparative study of the protein C pathway in septic and nonseptic patients with organ failure.},
  author={Delphine Borgel and Caroline Bornstain and Pieter H. Reitsma and Nicolas Lerolle and Sophie Gandrille and Fouad Dali-Ali and Charles T. Esmon and J. -Y. Fagon and Martine Aiach and J E Diehl},
  journal={American journal of respiratory and critical care medicine},
  year={2007},
  volume={176 9},
  pages={878-85}
}
RATIONALE Severe sepsis is associated with an exacerbated procoagulant state with protein C (PC) system impairment. In contrast, the inflammatory and coagulation status of nonseptic patients with organ failure (OF) is less documented. OBJECTIVES To compare coagulation activation, focusing on the PC system, and inflammatory status in septic and nonseptic patients with OF. METHODS Thirty patients with severe sepsis and 30 nonseptic patients were recruited at the onset of OF and compared with… CONTINUE READING