A comparative study of the effects of aging on the responsiveness of the cholinergic receptor of the isolated ileum of mouse and rat.

@article{Ochillo1988ACS,
  title={A comparative study of the effects of aging on the responsiveness of the cholinergic receptor of the isolated ileum of mouse and rat.},
  author={Richard Ochillo and Chien-Sung Tsai},
  journal={Research communications in chemical pathology and pharmacology},
  year={1988},
  volume={60 2},
  pages={261-4}
}
The responsiveness of the cholinergic receptor (ChR) of the isolated ileum of mouse and rat was characterized by determining the ED50 of acetylcholine (ACh) and pA2 of mepenzolate (MPZ) in tissues from animals of different ages. The ages (in months) of mice were 3, 6 and 18 and; 3, 6, 12 and 24 for rats respectively. The responsiveness of ChR in mice and rats decreased with age. There was no difference in the pA2 between the preparations derived from mice and rats nor was it affected by age… CONTINUE READING