A comparative study of the cytogenetic and antineoplastic effects induced by steroidal amidoesters of p-N, N-bis (2-chloroethyl) aminophenylbutyric acid (chlorambucil)
@article{Papageorgiou1996ACS, title={A comparative study of the cytogenetic and antineoplastic effects induced by steroidal amidoesters of p-N, N-bis (2-chloroethyl) aminophenylbutyric acid (chlorambucil)}, author={A. Papageorgiou and P. Catsoulacos and D. Catsoulacos and D. Mourelatos and E. Mioglou-Kalouptsi and Z. Iakovidou-Kritsi and L. Boutis and A. Kotsis}, journal={Cancer Journal}, year={1996}, volume={9}, pages={203-206} }
L'effet de quatre stereoisomers d'amidoesters steroidaux avec de l'acide p-N, N-bis (2-chloroethyl) aminophenylbutyric (chlorambucil) sur les echanges de chromatides soeur (SCE) et sur les cinetiques de proliferation de lymphocyte humain a ete teste. Une correlation dans ce groupe de quatre composes entre l'ampleur de la reponse SCE et la baisse de l'indice du taux de proliferation a ete observee. L'activite antitumorale des meme composes a ete testee sur des souris porteuses d'une leucemie… CONTINUE READING
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