A comparative study of structures and structural transitions of secondary transporters with the LeuT fold

@inproceedings{Jeschke2012ACS,
  title={A comparative study of structures and structural transitions of secondary transporters with the LeuT fold},
  author={Gunnar Jeschke},
  booktitle={European Biophysics Journal},
  year={2012}
}
Secondary active transporters from several protein families share a core of two five-helix inverted repeats that has become known as the LeuT fold. The known high-resolution protein structures with this fold were analyzed by structural superposition of the core transmembrane domains (TMDs). Three angle parameters derived from the mean TMD axes correlate with accessibility of the central binding site from the outside or inside. Structural transitions between distinct conformations were analyzed… CONTINUE READING

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