A comparative study of mouse liver proteins arylated by reactive metabolites of acetaminophen and its nonhepatotoxic regioisomer, 3'-hydroxyacetanilide.

@article{Myers1995ACS,
  title={A comparative study of mouse liver proteins arylated by reactive metabolites of acetaminophen and its nonhepatotoxic regioisomer, 3'-hydroxyacetanilide.},
  author={Timothy G. Myers and Ekkehardt Dietz and Neil Lennart Anderson and Edward A. Khairallah and Steven D. Cohen and Sidney D. Nelson},
  journal={Chemical research in toxicology},
  year={1995},
  volume={8 3},
  pages={
          403-13
        }
}
Acetaminophen (4'-hydroxyacetanilide), a widely used analgesic/antipyretic drug, is hepatotoxic in large doses, whereas the m-hydroxy isomer of acetaminophen, 3'-hydroxyacetanilide, is not hepatotoxic. Both are oxidized by mouse liver cytochromes P-450 to reactive metabolites that bind covalently to hepatic proteins. Because previous studies have shown that peak levels of liver protein adducts formed after the administration of each of these compounds to mice are nearly equivalent, and because… CONTINUE READING
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