A comparative study of methylglyoxal metabolism in trypanosomatids

@inproceedings{Greig2009ACS,
  title={A comparative study of methylglyoxal metabolism in trypanosomatids},
  author={Neil Greig and Susan Wyllie and Stephen H Patterson and Alan H. Fairlamb},
  booktitle={The FEBS journal},
  year={2009}
}
The glyoxalase system, comprising the metalloenzymes glyoxalase I (GLO1) and glyoxalase II (GLO2), is an almost universal metabolic pathway involved in the detoxification of the glycolytic byproduct methylglyoxal to d-lactate. In contrast to the situation with the trypanosomatid parasites Leishmania major and Trypanosoma cruzi, this trypanothione-dependent… CONTINUE READING