A comparative study of experimental caecal amoebiasis and the evaluation of amoebicides.

  title={A comparative study of experimental caecal amoebiasis and the evaluation of amoebicides.},
  author={Kamlesh K. Bhopale and K. S. Pradhan and Kaori Masani and Chaman Lal Kaul},
  journal={Annals of tropical medicine and parasitology},
  volume={89 3},
Caecal amoebiasis models (mouse, hamster and rat) were compared for amoebic infection and chemotherapeutic evaluation using a pathogenic strain of Entamoeba histolytica of human origin. Caecal infection in the hamster was of the acute type, with a large number of amoebae in the caecal tissue, whereas the amoebae in rats were seen in the lumen, on the mucosal surface. Amoebic lesions in the mouse caecum were of moderate severity. The mouse model responded to both metronidazole (tissue amoebicide… Expand
Caecal-inoculation of entamoeba histolytica in the immunodepressed swiss albino mice treated with Cyclophosphamide
The culture results of the stool of the mice which were inoculated with the inoculum of E. histolytica were found to be positive on the first 10 days after post caecal inoculation, and the antiamoebic antibody levels of all animals were also found negative. Expand
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Effects of Piper longum fruit, Piper sarmentosum root and Quercus infectoria nut gall on caecal amoebiasis in mice.
The severity of caecal wall ulceration was reduced in mice which received the extract and metronidazole as compared to the control animals. Expand
Phyllanthus piscatorum, ethnopharmacological studies on a women's medicinal plant of the Yanomamï Amerindians.
Although in several communities along the upper Orinoco the cultivation and use of Phyllanthus piscatorum is being lost because of the ongoing acculturation, the traditional medicinal use might provide an effective and cheap remedy against dermatological diseases linked with Candida albicans infections. Expand
Effects of Crude Root Extracts of Senna Didymobotrya on Caecal Amoebiasis in Mice
Anti-amoebic effects of crude root extracts of Senna didymobotrya against Entamoeba histolytica infecting caecum of mice were studied. Caecal amoebiasis was induced by injection of EntamoebaExpand


Intestinal invasive amebiasis: an experimental model in rodents using axenic or monoxenic strains of Entamoeba histolytica.
A new experimental model for the production of early stages of invasive intestinal amebiasis in hamsters or guinea pigs with axenic or monoxenic cultures of Entamoeba histolytica of the HM1:IMSSExpand
Activity of a new oxadiazole compound, against experimental infections with Entamoeba histolytica and Giardia lamblia in animal models.
BTI 2286E is more potent than metronidazole in extra intestinal, intra luminal amoebiasis models and has significant advantages in that it is non-mutagenic in the Ames test and has a shorter duration of effective treatment. Expand
The presence of Endamoeba histolytica in the liver of guinea pigs with experimental intestinal amebiasis.
The data are too meager to indicate a relationship between the severity of the intestinal lesions and the occurrence of the parasite in the liver, but in a series of cases not tabulated here, there was no parasitism of the liver when the intestinal infection was detectable only by finding parasites within the lumen without demonstrable lesions in the wall. Expand
A mouse model for Entamoeba histolytica infection
  • D. Owen
  • Biology, Medicine
  • Laboratory animals
  • 1985
2 strains of Entamoeba histolytica were administered intra-intestinally to 15 inbred and 3 outbred strains of mouse and both zymodemes were found to be capable of infecting all 18 strains of mice for varying periods of time and both were capable of invading the gut mucosa in genetically susceptible strains. Expand
Some observations on the variation of virulence and response to chemotherapy of strains of Entamoeba histolytica in rats.
  • R. Neal
  • Biology, Medicine
  • Transactions of the Royal Society of Tropical Medicine and Hygiene
  • 1951
The experimental infections of rats with various strains of E.V. histolytica showed that the virulence varies considerably, strains isolated from acute relapsing cases are all virulent to rats, but those from contact carriers may be avirulent or virulent. Expand
Comparative studies on the amoebicidal activity of known 5-nitroimidazole derivatives and CG 10213-Go in golden hamsters, Mesocricetus auratus, infected in the liver or caecum or both with trophozoites of Entamoeba histolytica.
CG 10213-Go, a 5-nitroimidazole derivative synthesized at the CIBA-Geigy Research Centre, Bombay, proved superior to such currently used 5-nitroimidazole derivatives as metronidazole, ornidazole,Expand
Comparative efficacy of metronidazole and another 5-nitroimidazole, CG-10213-Go, in caecal amoebiasis in albino mice (Mus musculus).
The compound CG-10213-Go was found to be superior to metronidazole in a mouse model of caecal amoebiasis. Expand
The effect of bisamidines of 2,6-diaminoanthraquinone onEntamoeba histolytica infections in rats and hamsters
Bisamidines of 2,6-diaminoanthraquinone have demonstrated potent activity against cecal and hepaticEntamoeba histolytica infections in rats and hamsters, respectively. A number of these compoundsExpand