A comparative study of artificial membrane permeability assay for high throughput profiling of drug absorption potential.

@article{Zhu2002ACS,
  title={A comparative study of artificial membrane permeability assay for high throughput profiling of drug absorption potential.},
  author={Chengyue Zhu and Lan Jiang and Teng-Man Chen and Kin-Kai Hwang},
  journal={European journal of medicinal chemistry},
  year={2002},
  volume={37 5},
  pages={399-407}
}
Artificial membrane permeability measurement is a potentially high throughput and low cost alternative for in vitro assessment of drug absorption potential. It will be an ideal screening/profiling tool in the lead generation program of drug discovery research if it is proven to be generally applicable for classifying drug absorption potential and is advantageous over other in vitro or in silico methods. This study provides an in-depth evaluation of the method in close comparison to Caco-2, LogD… CONTINUE READING
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