A comparative study of Lrrk2 function in primary neuronal cultures.

  title={A comparative study of Lrrk2 function in primary neuronal cultures.},
  author={Justus Alfred Daechsel and Bahareh Behrouz and Mei Y Yue and Joel E. Beevers and Heather L. Melrose and Matthew J Farrer},
  journal={Parkinsonism & related disorders},
  volume={16 10},
OBJECTIVE To assess the contribution of wild-type, mutant and loss of leucine-rich repeat kinase-2 (LRRK2; Lrrk2) on dendritic neuronal arborization. BACKGROUND LRRK2 mutations are recognized as the major genetic determinant of susceptibility to Parkinson's disease for which a cellular assay of Lrrk2 mutant function would facilitate the development of targeted molecular therapeutics. METHODS Dendritic neuronal arborization (neurite length, branching and the number of processes per cell) was… CONTINUE READING
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