A comparative study of 131I and 177Lu labeled somatostatin analogues for therapy of neuroendocrine tumours.

Abstract

This work analysed the influence of the chelating group and radioligand on somatostatin analogues in vivo and in vitro properties. The presence of DOTA in the radioiodinated peptide produced a labeled analogue with similar blood kinetics and biodistribution to (177)Lu-DOTATATE and with lower abdominal uptake than (131)I-TATE. In addition, (131)I-DOTATATE… (More)
DOI: 10.1016/j.apradiso.2008.09.009

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