A comparative study in vitro of physiological activity of triterpene glycosides of marine invertebrates of echinoderm type.

  title={A comparative study in vitro of physiological activity of triterpene glycosides of marine invertebrates of echinoderm type.},
  author={T. Kuznetsova and M. M. Anisimov and A. M. Popov and S. Baranova and S. Afiyatullov and I. Kapustina and A. Antonov and G. B. Elyakov},
  journal={Comparative biochemistry and physiology. C: Comparative pharmacology},
  volume={73 1},
1. The cytostatic and antimicrobial activity of triterpene glycosides of 19 holothurian species of the Pacific tropical zone has been studied. 2. It has been demonstrated that yeast and tumor cells display a comparable sensibility to the action of triterpene oligosides of sea cucumbers. 3. Gram-positive and Gram-negative bacteria are not sensible to the action of glycosides in doses to 500 mkg/ml. 4. Triterpene glycosides-stichoposides, thelothurins and oligosides of Holothuria of genus… Expand
Relationships between chemical structures and functions of triterpene glycosides isolated from sea cucumbers
The structural characteristics of marine triterpene glycosides and how these affect their biological activities and molecular mechanisms are reviewed, with a focus on structure-activity relationships. Expand
The biological action of saponins in animal systems: a review.
Saponins are steroid or triterpenoid glycosides, common in a large number of plants and plant products that are important in human and animal nutrition and they have also been found to significantly affect growth, feed intake and reproduction in animals. Expand
Recent developments in the field of marine natural products with emphasis on biologically active compounds.
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  • Chemistry, Medicine
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  • 1986
The marine flora and animal world are a rich source of biologically active compounds and among the best known of the toxic substances are tetrodotoxin, saxitoxin, and the polypeptides from sea anemones, but they will not be the main subject of this report. Expand
Are echinoderms of interest to biotechnology?
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  • Biology, Medicine
  • Progress in molecular and subcellular biology
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Examples are presented that show the usefulness of echinoderm-derived molecules for therapeutic application in selected fields of cancer research, in the control of bacterial growth as substances with new antibiotic properties, and finally in the context of technical applications such as antifouling substances. Expand
Study of antibacterial effect of the extracts of the sea cucumber (Holothuria leucospilota) of Persian Gulf on the Escherichia coli
The antibacterial effect of the extracts of body wall, gonads and intestine was studied on the E.coli at several concentrations and minimum inhibitory concentration and minimum bactericidal concentration of the extract were studied against bacteria. Expand
Distribution of Saponins in the Sea Cucumber Holothuria lessoni; the Body Wall Versus the Viscera, and Their Biological Activities
The structure of four novel acetylated saponins, namely lessoniosides H, I, J, and K were characterized and identified triterpene glycosides showed potent antifungal activities against tested fungi, but had no antibacterial effects on the bacterium Staphylococcus aureus. Expand
Investigation of two echinoderms from Abu-Qir region of Alexandria Mediterranean coast revealed Gram-positive bacteria from the gonads of the sea urchin and two types of pathogenic fungi from its digestive tract and no isolates were detected from the sea cucumber. Expand
Chemical Biodiversity and Bioactivities of Saponins in Echinodermata with an Emphasis on Sea Cucumbers (Holothuroidea)
The here presented data revealed that holothurians, holotoxins, cucumariosides, and echinosids are not only the most abundant saponin compounds in various genera of sea cucumbers but that these saponins can also be used as potential chemotaxonomic markers for different sea cucumber species. Expand
Echinoderms: A Review of Bioactive Compounds With Potential Health Effects
This chapter focuses on the phylum Echinodermata and aims at summarizing and highlighting the BCs derived from echinoderms discovered between 2009 and 2014 with beneficial health effects, clarifying their structure, distribution, biosynthetic origin, biological activity, and when applied, their mode of action. Expand
Jewel of the seabed: sea cucumbers as nutritional and drug candidates
  • P. Kiew, M. M. Don
  • Biology, Medicine
  • International journal of food sciences and nutrition
  • 2012
Its numerous bioactive compounds, such as triterpene glycosides, glycosaminoglycans, gangliosides, collagen, branched-chain fatty acid and lectins, serve as potential sources of neutraceutical, pharmaceutical and cosmetic agents, thus providing a new platform in biochemical research. Expand


Chemical studies of marine invertebrates-XXI. Six triterpene genins artifacts from thelothurins A and B, toxic saponins of the sea cucumber Thelonota ananas Jaeger (echinodermata). Biosynthesis of the thelothurins
Abstract Aqueous hydrochloric acid hydrolysis of the mixture of thelothurins A and B, the saponins from the sea cucumber Thelonota ananas Jaeger, gave a complex mixture from which six sapogenins wereExpand
Antifungal Steroid Glycoside from Sea Cucumber
An antifungal steroid glycoside, holotoxin, has been isolated from the sea cucumber Stichopus japonicus (Selenka). In vitro, it exhibits high activity against various fungi, including vegetableExpand
Structures of Echinoside A and B, Two Antifungal Oligoglycosides from the Sea Cucumber Actinopyga echinites (JAEGER)
On the basis of chemical and physicochemical evidence, the structures of two antifungal oligoglycosides, echinoside A and B from the sea cucumber Actinopyga echinites (JAEGER), have been elucidatedExpand
Structure of holothurin B a pharmacologically active triterpene-oligoglycoside from the sea cucumber holothuria leucospilota brandt
On the basis of chemical and physicochemical evidence, the structure of holothurin A, a biologically active major obligoglycoside o lanostane-type triterpene holothurigenol (2), has been elucidatedExpand
Structures of four new triterpenoidal oligoglycosides, bivittoside A,B,C, and D, from the sea cucumber Bohadschia bivittata Mitsukuri.
On the basis of chemical and physicochemical evidence, the structures of four triterpenoidal oligoglycosides, bivittoside A, B, C, and D from the sea cucumber Bohadschia bivittata MITSUKURI, haveExpand
Some Biological Characteristics of Holothurin
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  • Biology, Medicine
  • Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine
  • 1952
Summary Holothurin, a thermostable toxic factor derived from the Organ of Cuvier of the Caribbean sea cucumber, acts as a powerful poison to several protozoa grown in pure culture. The same materialExpand
Antineoplastic agents XLV: sea cucumber cytotoxic saponins.