A comparative study between nanoparticle-targeted therapeutics and bioconjugates as obesity medication.

@article{Hossen2013ACS,
  title={A comparative study between nanoparticle-targeted therapeutics and bioconjugates as obesity medication.},
  author={Nazir Hossen and K. Kajimoto and H. Akita and M. Hyodo and H. Harashima},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2013},
  volume={171 2},
  pages={
          104-12
        }
}
Antiangiogenesis has been the focus of a new strategy for the treatment of obesity. However, little is known regarding the issue of whether targeting angiogenesis by nanoparticle-targeted therapeutic is advantageous or not in debugging the co-morbidity associated with diet-induced obesity (DIO) and the metabolic syndrome. We report herein on the positive effect of prohibitin (an adipose vascular marker)-targeted nanoparticle (PTNP) encapsulated in a proapoptotic peptide [(D)(KLAKLAK)₂, KLA] on… Expand
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