A comparative repair study of thymine- and uracil-photodimers with model compounds and a photolyase repair enzyme.

@article{Butenandt2000ACR,
  title={A comparative repair study of thymine- and uracil-photodimers with model compounds and a photolyase repair enzyme.},
  author={Jens Butenandt and Robert Epple and E U Wallenborn and Andr{\'e} Eker and Volker Gramlich and Thomas Carell},
  journal={Chemistry},
  year={2000},
  volume={6 1},
  pages={62-72}
}
Cyclobutane uridine and thymidine dimers with cis-syn-structure are DNA lesions, which are efficiently repaired in many species by DNA photolyases. The essential step of the repair reaction is a light driven electron transfer from a reduced FAD cofactor (FADH ) to the dimer lesion, which splits spontaneously into the monomers. Repair studies with UV-light damaged DNA revealed significant rate differences for the various dimer lesions. In particular the effect of the almost eclipsed positioned… CONTINUE READING
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