A comparative evaluation of ultrasound molecular imaging, perfusion imaging, and volume measurements in evaluating response to therapy in patient-derived xenografts.

@article{Streeter2013ACE,
  title={A comparative evaluation of ultrasound molecular imaging, perfusion imaging, and volume measurements in evaluating response to therapy in patient-derived xenografts.},
  author={Jason E. Streeter and Silvia Gabriela Herrera-Loeza and Nicole F. Neel and Jen Jen J. Yeh and Paul A. Dayton},
  journal={Technology in cancer research & treatment},
  year={2013},
  volume={12 4},
  pages={311-21}
}
Most pre-clinical therapy studies use the change in tumor volume as a measure for disease response. However, tumor size measurements alone may not reflect early changes in tumor physiology that occur as a response to treatment. Ultrasonic molecular imaging (USMI) and Dynamic Contrast Enhanced-Perfusion Imaging (DCE-PI) with ultrasound are two attractive alternatives to tumor volume measurements. Since these techniques can provide information prior to the appearance of gross phenotypic changes… CONTINUE READING