A comparative analysis of the time-dependent antiproliferative effects of daunorubicin and WP631.

@article{Villamarn2003ACA,
  title={A comparative analysis of the time-dependent antiproliferative effects of daunorubicin and WP631.},
  author={S. Villamar{\'i}n and Sylvia Mansilla and N. Ferrer-Miralles and W. Priebe and J. Portugal},
  journal={European journal of biochemistry},
  year={2003},
  volume={270 4},
  pages={
          764-70
        }
}
Jurkat T lymphocytes were treated with daunorubicin and WP631, a daunorubicin-based DNA binding agent, in experiments aimed to analyze cellular uptake of these drugs and their effect on cell viability. WP631 was taken up more slowly than daunorubicin, but laser confocal microscopy and spectrofluorometric quantification showed that the drug accumulated in the cells. Despite the slow uptake rate, the antiproliferative capacity of WP631 (measured as IC50 after a 72-h continuous treatment) was… Expand
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