A commonly used Chinese herbal formula, Shu-Jing-Hwo-Shiee-Tang, potentiates anticoagulant activity of warfarin in a rabbit model.

@article{Yang2013ACU,
  title={A commonly used Chinese herbal formula, Shu-Jing-Hwo-Shiee-Tang, potentiates anticoagulant activity of warfarin in a rabbit model.},
  author={Sien-Hung Yang and C G Yu and Hsing-Yu Chen and Yi-Hsuan Lin},
  journal={Molecules},
  year={2013},
  volume={18 10},
  pages={11712-23}
}
BACKGROUND Drug interactions between traditional Chinese herbal medicines and the anticoagulant warfarin may cause patient harm and are, therefore, important in clinical practice. Our experience in daily practice suggests that prothrombin time (PT) is prolonged when warfarin is used in combination with the Chinese herbal formula Shu-Jing-Hwo-Shiee-Tang (SJHST) commonly used by patients with osteoarthritis. OBJECTIVE We conducted animal experiments to confirm the effect of SJHST and warfarin… CONTINUE READING
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Estimating the Maximum Safe Starting Dose in Initial Clinical Trials for Therapeutics in Adult Healthy Volunteers

  • U. S. Department of Health, Human Services, Food, Drug Administration, Center for Drug Evaluation, Research CDER. Guidance for Industry
  • Available online: http://www.fda.gov/downloads…
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