A common variant on chromosome 9p21 affects the risk of myocardial infarction.

  title={A common variant on chromosome 9p21 affects the risk of myocardial infarction.},
  author={Anna Helgadottir and Gudmar Thorleifsson and Andrei Manolescu and S{\'o}lveig Gr{\'e}tarsd{\'o}ttir and Thorarinn Blondal and Aslaug Jonasdottir and Adalbjorg Jonasdottir and Asgeir Sigurdsson and Adam Baker and Arnar Palsson and G{\'i}sli M{\'a}sson and Daniel Fannar Gudbjartsson and Kristinn P. Magnusson and Karl Andersen and Allan I. Levey and Valgerdur M. Backman and Sigurborg Matthiasdottir and Thorbjorg Jonsdottir and Stefan Th. Palsson and Helga Einarsd{\'o}ttir and Steinunn Gunnarsdottir and Arnaldur Gylfason and Viola Vaccarino and William Craig Hooper and Muredach P. Reilly and Christopher B. Granger and Harland Austin and Daniel J. Rader and Svati H. Shah and Arshed A Quyyumi and Jeffrey Robert Gulcher and Gudmundur Thorgeirsson and Unnur Thorsteinsdottir and Augustine Kong and K{\'a}ri Stef{\'a}nsson},
  volume={316 5830},
The global endemic of cardiovascular diseases calls for improved risk assessment and treatment. Here, we describe an association between myocardial infarction (MI) and a common sequence variant on chromosome 9p21. This study included a total of 4587 cases and 12,767 controls. The identified variant, adjacent to the tumor suppressor genes CDKN2A and CDKN2B, was associated with the disease with high significance. Approximately 21% of individuals in the population are homozygous for this variant… CONTINUE READING
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