A common variant of the PAX2 gene is associated with reduced newborn kidney size.

@article{Quinlan2007ACV,
  title={A common variant of the PAX2 gene is associated with reduced newborn kidney size.},
  author={Jacklyn Quinlan and Mathieu F. Lemire and Thomas A. Hudson and Huiqi Qu and A. Hoff Benjamin and Anne Roy and Elena Pascuet and Meigan Gates. Goodyer and Chandhana Raju and Zhao Zhang and Fiona Houghton and Paul Goodyer},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2007},
  volume={18 6},
  pages={
          1915-21
        }
}
Congenital nephron number ranges widely in the human population. Suboptimal nephron number may be associated with increased risk for essential hypertension and susceptibility to renal injury, but the factors that set nephron number during kidney development are unknown. In renal-coloboma syndrome, renal hypoplasia and reduced nephron number are due to heterozygous mutations of the PAX2 gene. This study tested for an association between a common haplotype of the PAX2 gene and subtle renal… CONTINUE READING

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