A common variant of the AMPD1 gene predicts improved cardiovascular survival in patients with coronary artery disease.

@article{Anderson2000ACV,
  title={A common variant of the AMPD1 gene predicts improved cardiovascular survival in patients with coronary artery disease.},
  author={Jeffrey L Anderson and Jennifer P Habashi and John F. Carlquist and Joseph Brent Muhlestein and Benjamin D. Horne and Tami L. Bair and Robert R. Pearson and Noal I Hart},
  journal={Journal of the American College of Cardiology},
  year={2000},
  volume={36 4},
  pages={1248-52}
}
OBJECTIVE We tested whether a common AMPD1 gene variant is associated with improved cardiovascular (CV) survival in patients with coronary artery disease (CAD). BACKGROUND Reduced activity of adenosine monophosphate deaminase (AMPD) may increase production of adenosine, a cardioprotective agent. A common, nonsense, point variant of the AMPD1 gene (C34T) results in enzymatic inactivity and has been associated with prolonged survival in heart failure. METHODS Blood was collected from 367… CONTINUE READING