A common variant in the peroxisome proliferator-activated receptor-γ coactivator-1α gene is associated with nonalcoholic fatty liver disease in obese children.

@article{Lin2013ACV,
  title={A common variant in the peroxisome proliferator-activated receptor-γ coactivator-1α gene is associated with nonalcoholic fatty liver disease in obese children.},
  author={Yu-Cheng Lin and P Chang and M. -O. Chang and Y. -S. Ni},
  journal={The American journal of clinical nutrition},
  year={2013},
  volume={97 2},
  pages={
          326-31
        }
}
BACKGROUND The single nucleotide polymorphism in the peroxisome proliferator-activated receptor-γ coactivator (PGC)-1α gene (PPARGC1A) was identified to be associated with nonalcoholic fatty liver disease (NAFLD) in adults. The PPARGC1A gene encodes PGC-1α, which regulates cellular energy metabolism. OBJECTIVE We aimed to test the hypothesis that the PPARGC1A rs8192678 risk A allele would influence the risk of NAFLD in obese children. DESIGN We genotyped PPARGC1A rs8192678 and PNPLA3… CONTINUE READING
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