A common variant in PNPLA3, which encodes adiponutrin, is associated with liver fat content in humans

@article{Kotronen2009ACV,
  title={A common variant in PNPLA3, which encodes adiponutrin, is associated with liver fat content in humans},
  author={Anna Kotronen and Lovisa E. Johansson and Lina M. Johansson and Christophe Roos and Jukka Westerbacka and Anders Hamsten and Robert Bergholm and Perttu Arkkila and Johanna Arola and Tuula Kiviluoto and Rachel M. Fisher and Ewa E Ehrenborg and Marju Orho-Melander and Martin Ridderstr{\aa}le and Leif Groop and Hannele Yki-J{\"a}rvinen},
  journal={Diabetologia},
  year={2009},
  volume={52},
  pages={1056-1060}
}
It has recently been suggested that the rs738409 G allele in PNPLA3, which encodes adiponutrin, is strongly associated with increased liver fat content in three different ethnic groups. The aims of the present study were as follows: (1) to try to replicate these findings in European individuals with quantitative measures of hepatic fat content; (2) to study whether the polymorphism influences hepatic and adipose tissue insulin sensitivity; and (3) to investigate whether PNPLA3 expression is… CONTINUE READING
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A new gene regulated by energy balance in human adipose tissue

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