A common variant at the TERT-CLPTM1L locus is associated with estrogen receptor–negative breast cancer

  title={A common variant at the TERT-CLPTM1L locus is associated with estrogen receptor–negative breast cancer},
  author={Christopher A. Haiman and Gary K. Chen and Celine M. Vachon and Frederico Canzian and Alison M. Dunning and Robert C. Millikan and Xianshu Wang and Foluso Ademuyiwa and Shahana Ahmed and Christine B. Ambrosone and Laura Baglietto and Rosemary L. Balleine and Elisa V. Bandera and Matthias W. Beckmann and C. T. van den Berg and Leslie Bernstein and Carl Blomqvist and William J. Blot and Hiltrud Brauch and Julie E. Buring and Lisa A. Carey and Jane E. Carpenter and Jenny Chang-Claude and Stephen J. Chanock and Daniel Chasman and Christine L. Clarke and Angela Cox and Simon S. Cross and Sandra L. Deming and Robert B. Diasio and Athanasios Meletios Dimopoulos and William Driver and Thomas D{\"u}nnebier and Lorraine T Durcan and Diana Eccles and Christopher K. Edlund and Arif B. Ekici and Peter A. Fasching and Heather Spencer Feigelson and Dieter Flesch-Janys and Florentia Fostira and Asta Foersti and George Fountzilas and Susan M. Gerty and Graham G. Giles and Andrew K. Godwin and Paul J Goodfellow and Nikki J. Graham and Dario Greco and Ute Hamann and Susan E. Hankinson and Arndt Hartmann and Rebecca Hein and Judith Heinz and Andrea E Holbrook and Robert Nathaniel Hoover and Jennifer Hu and David J. Hunter and Sue Ann Ingles and Astrid Irwanto and Jennifer L. Ivanovich and Esther M John and Nicola F. Johnson and Arja Jukkola-Vuorinen and Rudolf Kaaks and Y D Ko and Laurence N. Kolonel and Irene Konstantopoulou and Veli-Matti Kosma and Swati A. Kulkarni and Diether Lambrechts and Adam M. Lee and Lo{\"i}c Le Marchand and Timothy Lesnick and Jianping Liu and Sara Lindstrom and Arto J Mannermaa and Sara Margolin and Nicholas G. Martin and Penelope L. Miron and Grant W. Montgomery and Heli Nevanlinna and Stephan Nickels and Sarah J. Nyante and Curtis L Olswold and J R Palmer and Harsh mohan Pathak and Dimitrios G Pectasides and Charles M. Perou and Julian Peto and Paul D P Pharoah and Loreall C. Pooler and Michael F Press and Katri Pylk{\"a}s and Timothy R. Rebbeck and Jorge L. Rodriguez-Gil and Lynn Rosenberg and Eric Ross and Thomas Ruediger and Isabel M dos Santos Silva and Elinor J. Sawyer and Marjanka K. Schmidt and R{\"u}diger Schulz-Wendtland and Fredrick R Schumacher and Gianluca Severi and Xin Sheng and Lisa B. Signorello and H. -P. Sinn and Kristen Stevens and Melissa C. Southey and William Tapper and Ian Tomlinson and Frans Hogervorst and Els Wauters and Joellen Weaver and Hans Wildiers and Robert Winqvist and David J. Van Den Berg and Peggy C Wan and Lucy Xia and Drakoulis Yannoukakos and Wei Zheng and Regina G Ziegler and A Mohammed Siddiq and Susan L. Slager and Daniel O. Stram and Douglas F. Easton and Peter Kraft and Brian E. Henderson and Fergus J. Couch},
  journal={Nature Genetics},
Estrogen receptor (ER)-negative breast cancer shows a higher incidence in women of African ancestry compared to women of European ancestry. In search of common risk alleles for ER-negative breast cancer, we combined genome-wide association study (GWAS) data from women of African ancestry (1,004 ER-negative cases and 2,745 controls) and European ancestry (1,718 ER-negative cases and 3,670 controls), with replication testing conducted in an additional 2,292 ER-negative cases and 16,901 controls… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 3 times over the past 90 days. VIEW TWEETS


Publications citing this paper.
Showing 1-10 of 145 extracted citations


Publications referenced by this paper.
Showing 1-10 of 17 references

Genome-wide association study of renal cell carcinoma identifies two susceptibility loci on 2p21 and 11q13.3

  • Purdue, M.P
  • Nat. Genet
  • 2011

Genome - wide association study identifies five new breast cancer susceptibility loci

  • C. Turnbull
  • Nat . Genet .
  • 2010

Genome-wide association study identifies five new breast cancer susceptibility

  • C Turnbull
  • loci. Nat. Genet
  • 2010

Genome-wide association study identifies five susceptibility loci for glioma

  • S Shete
  • Nat. Genet
  • 2009

survey in indigenous African women reveals over-representation of triple-negative breast cancer

  • Huo, D. et al. Population differences in breast cancer
  • J. Clin. Oncol. 27, 4515–4521
  • 2009

Similar Papers

Loading similar papers…