A common thrombomodulin amino acid dimorphism is associated with myocardial infarction.

@article{Norlund1997ACT,
  title={A common thrombomodulin amino acid dimorphism is associated with myocardial infarction.},
  author={Lena K. Norlund and Johan Holm and Bengt Z{\"o}ller and A K Ohlin},
  journal={Thrombosis and haemostasis},
  year={1997},
  volume={77 2},
  pages={248-51}
}
Endothelial dysfunction and haemostatic imbalance are believed to be important aetiological factors in the development of acute coronary syndromes. Thrombomodulin (TM) is an integral membrane protein crucial for normal endothelial function and activation of the protein C anticoagulant pathway. We have investigated the importance of a common C/T dimorphism in the TM gene (nucleotide 1418) for development of premature myocardial infarction (MI). The C/T dimorphism predicts an Ala455 to Val… CONTINUE READING

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