A common structural motif in thiamin pyrophosphate-binding enzymes.

@article{Hawkins1989ACS,
  title={A common structural motif in thiamin pyrophosphate-binding enzymes.},
  author={Clifford F. Hawkins and Anita Borges and Richard N. Perham},
  journal={FEBS letters},
  year={1989},
  volume={255 1},
  pages={77-82}
}
The amino acid sequences of a wide range of enzymes that utilize thiamin pyrophosphate (TPP) as cofactor have been compared. A common sequence motif approximately 30 residues in length was detected, beginning with the highly conserved sequence -GDG- and concluding with the highly conserved sequence -NN-. Secondary structure predictions suggest that the motif may adopt a beta alpha beta fold. The same motif was recognised in the primary structure of a protein deduced from the DNA sequence of a… CONTINUE READING

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