A common region of homozygous deletion in malignant human gliomas lies between the IFN alpha/omega gene cluster and the D9S171 locus.

@article{Ichimura1994ACR,
  title={A common region of homozygous deletion in malignant human gliomas lies between the IFN alpha/omega gene cluster and the D9S171 locus.},
  author={Kazuya Ichimura and Esther E. Schmidt and Nozomi Yamaguchi and C. David James and Vincent Peter Collins},
  journal={Cancer research},
  year={1994},
  volume={54 12},
  pages={3127-30}
}
Deletions of the 9p-localized type-I interferon (IFN) genes and adjacent loci often occur during the development of malignant glioma. We have applied restriction fragment length polymorphism and microsatellite analysis to 12 loci covering this region of 9p and 3 loci on 9q in 74 human glial tumor tissues to define and further localize the smallest region of hemizygous or homozygous deletion common to the tumors. Three regions of homozygous deletion were evident among the panel of tumors; only… CONTINUE READING