A common polymorphism in the mineralocorticoid receptor modulates stress responsiveness.

@article{Derijk2006ACP,
  title={A common polymorphism in the mineralocorticoid receptor modulates stress responsiveness.},
  author={Roel H Derijk and Stefan W{\"u}st and Onno C. Meijer and Maria-Christina Zennaro and Ilona S Federenko and Dirk H. Hellhammer and Gilberta Giacchetti and E. Vreugdenhil and Frans G Zitman and Edo Ronald de Kloet},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2006},
  volume={91 12},
  pages={5083-9}
}
CONTEXT Mineralocorticoid receptors (MR) mediate the action of aldosterone on sodium resorption in kidney tubular cells, but in brain they respond to the glucocorticoid cortisol in stress regulation and cognitive processes. OBJECTIVE The objective of the study was to investigate the role of the MR gene variant I180V in the neuroendocrine response to a psychosocial stressor and in electrolyte regulation. DESIGN Associations between the MRI180V and outcome variables in a healthy cohort… CONTINUE READING
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