A common polymorphism in the 5'-untranslated region of the VEGF gene is associated with diabetic retinopathy in type 2 diabetes.

@article{Awata2002ACP,
  title={A common polymorphism in the 5'-untranslated region of the VEGF gene is associated with diabetic retinopathy in type 2 diabetes.},
  author={Takuya Awata and Kiyoaki Inoue and Susumu Kurihara and Tomoko Ohkubo and Masaki Watanabe and Kouichi Inukai and Ikuo Inoue and Shigehiro Katayama},
  journal={Diabetes},
  year={2002},
  volume={51 5},
  pages={1635-9}
}
Vascular endothelial growth factor (VEGF), a major mediator of vascular permeability and angiogenesis, may play a pivotal role in mediating the development and progression of diabetic retinopathy. In the present study, we examined the genetic variations of the VEGF gene to assess its possible relation to diabetic retinopathy in type 2 diabetic patients. Among seven common polymorphisms in the promoter region, 5'-untranslated region (UTR) and 3'UTR of the VEGF gene, genotype distribution of the… CONTINUE READING
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