A common polymorphism in the 3'UTR of cyclooxygenase 2/prostaglandin synthase 2 gene and risk of lung cancer in a Chinese population.

@article{Hu2005ACP,
  title={A common polymorphism in the 3'UTR of cyclooxygenase 2/prostaglandin synthase 2 gene and risk of lung cancer in a Chinese population.},
  author={Zhibin Hu and Xiaoping Miao and Hongxia Ma and Xue-li Wang and Wen Tan and Qingyi Wei and Dongxin Lin and Hongbing Shen},
  journal={Lung cancer},
  year={2005},
  volume={48 1},
  pages={11-7}
}
Cyclooxygenases (COXs) are key enzymes that convert arachidonic acid to prostaglandins. Overexpression of COX-2, one of the COX isozymes, has been shown to be an early event in lung carcinogenesis and may play an important role in lung cancer development. A common single nucleotide polymorphism, T8473C, located within a potential functional region in the 3'UTR of COX-2 gene was identified and we hypothesized that this COX-2 variant is associated with lung cancer risk. To test this hypothesis… CONTINUE READING

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