A common polymorphism in TLR3 confers natural resistance to HIV-1 infection.

@article{Sironi2012ACP,
  title={A common polymorphism in TLR3 confers natural resistance to HIV-1 infection.},
  author={Manuela Sironi and Mara Biasin and Rachele Cagliani and Diego Forni and Mariacristina de Luca and Irma Saulle and Sergio lo Caputo and Francesco Mazzotta and Juan Mac{\'i}as and Juan Pineda and Antonio Caruz and Mario Clerici},
  journal={Journal of immunology},
  year={2012},
  volume={188 2},
  pages={818-23}
}
TLR3 recognizes dsRNA and activates antiviral immune responses through the production of inflammatory cytokines and type I IFNs. Genetic association studies have provided evidence concerning the role of a polymorphism in TLR3 (rs3775291, Leu412Phe) in viral infection susceptibility. We genotyped rs3775291 in a population of Spanish HIV-1-exposed seronegative (HESN) individuals who remain HIV seronegative despite repeated exposure through i.v. injection drug use (IDU-HESN individuals) as… CONTINUE READING