A common pattern of persistent gene activation in human neocortical epileptic foci.

@article{Rakhade2005ACP,
  title={A common pattern of persistent gene activation in human neocortical epileptic foci.},
  author={Sanjay N. Rakhade and B. G. Yao and Sharlin Ahmed and Eishi Asano and Thomas L. Beaumont and A. K. Shah and Sorin Draghici and Raul Krauss and Harry T. Chugani and Sandeep Sood and Jeffrey A. Loeb},
  journal={Annals of neurology},
  year={2005},
  volume={58 5},
  pages={736-47}
}
Epilepsy is a disease of recurrent seizures that can develop after a wide range of brain insults. Although surgical resection of focal regions of seizure onset can result in clinical improvement, the molecular mechanisms that produce and maintain focal hyperexcitability are not understood. Here, we demonstrate a regional, persistent induction of a common group of genes in human epileptic neocortex in 17 patients with neocortical epilepsy, regardless of the underlying pathology. This relatively… CONTINUE READING
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