A common mutation in the methylenetetrahydrofolate reductase gene (C677T) increases the risk for deep-vein thrombosis in patients with mutant factor V (factor V:Q506).

@article{Cattaneo1997ACM,
  title={A common mutation in the methylenetetrahydrofolate reductase gene (C677T) increases the risk for deep-vein thrombosis in patients with mutant factor V (factor V:Q506).},
  author={Mariana Cattaneo and Michael Y Tsai and Paolo Bucciarelli and Emanuela Taioli and Maddalena Loredana Zighetti and Marilyn Bignell and Pier Mannuccio Mannucci},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={1997},
  volume={17 9},
  pages={1662-6}
}
Hyperhomocysteinemia is a frequent risk factor for deep-vein thrombosis. A common mutation (C677T) in the gene encoding for methylenetetrahydrofolate reductase (MTHFR) is responsible, in the homozygous state, for decreased enzyme activity and mild hyperhomocysteinemia and is associated with increased risk for cardiovascular disease. We studied the prevalence of C677T MTHFR in 77 patients with deep-vein thrombosis and in 154 age- and sex-matched healthy control subjects. In the same individuals… CONTINUE READING
48 Citations
25 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 48 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 25 references

Similar Papers

Loading similar papers…