A common mutation in the 5,10-methylenetetrahydrofolate reductase gene affects genomic DNA methylation through an interaction with folate status.

Abstract

DNA methylation, an essential epigenetic feature of DNA that modulates gene expression and genomic integrity, is catalyzed by methyltransferases that use the universal methyl donor S-adenosyl-l-methionine. Methylenetetrahydrofolate reductase (MTHFR) catalyzes the synthesis of 5-methyltetrahydrofolate (5-methylTHF), the methyl donor for synthesis of… (More)

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Cite this paper

@article{Friso2002ACM, title={A common mutation in the 5,10-methylenetetrahydrofolate reductase gene affects genomic DNA methylation through an interaction with folate status.}, author={Simonetta Friso and Sang-Woon Choi and Domenico Girelli and Joel B. Mason and Gregory G. Dolnikowski and Pamela J. Bagley and Oliviero Olivieri and Paul F Jacques and Irwin H. Rosenberg and Roberto Corrocher and Jacob S Selhub}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={2002}, volume={99 8}, pages={5606-11} }