A common mitochondrial DNA variant and increased body mass index as associated factors for development of type 2 diabetes: Additive effects of genetic and environmental factors.

@article{Liou2007ACM,
  title={A common mitochondrial DNA variant and increased body mass index as associated factors for development of type 2 diabetes: Additive effects of genetic and environmental factors.},
  author={C W Liou and Tsu-Kung Lin and Hsu Huei Weng and Cheng-Feng Lee and Tzu-ling Chen and Yau-Huei Wei and Shang-Der Chen and Yao-Chung Chuang and Shao-Wen Weng and Pei-wen Wang},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2007},
  volume={92 1},
  pages={
          235-9
        }
}
OBJECTIVE The suggested correlation between a T-to-C transition at the nucleotide 16189 in mitochondrial DNA (mtDNA) with increasing insulin resistance and adult-onset diabetes mellitus (DM) is debatable. METHODS Our study examined mtDNA from 462 subjects with type 2 diabetes (T2DM) and 592 normoglycemic controls (non-DM). Each participant's body mass index (BMI), fasting plasma glucose, fasting insulin concentration, insulin resistance index, and beta-cell function were measured. Sequencing… CONTINUE READING

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