A common mechanism for blockade of heme polymerization by antimalarial quinolines.

@article{Sullivan1998ACM,
  title={A common mechanism for blockade of heme polymerization by antimalarial quinolines.},
  author={David J. Sullivan and Hugues Matile and Robert G. Ridley and Daniel E Goldberg},
  journal={The Journal of biological chemistry},
  year={1998},
  volume={273 47},
  pages={31103-7}
}
The antimalarial quinolines are believed to work by blocking the polymerization of toxic heme released during hemoglobin proteolysis in intraerythrocytic Plasmodium falciparum. In the presence of free heme, chloroquine and quinidine associate with the heme polymer. We have proposed that this association of the quinoline-heme complex with polymer caps the growing heme polymer, preventing further sequestration of additional heme that then accumulates to levels that kill the parasite. In this work… CONTINUE READING

From This Paper

Topics from this paper.
26 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 26 extracted citations

Similar Papers

Loading similar papers…