A common maturation pathway for small nucleolar RNAs.

  title={A common maturation pathway for small nucleolar RNAs.},
  author={Michael P Terns and Christian Grimm and Elsebet Lund and J. E. Dahlberg},
  journal={The EMBO journal},
  volume={14 19},
We have shown that precursors of U3, U8 and U14 small nucleolar RNAs (snoRNAs) are not exported to the cytoplasm after injection into Xenopus oocyte nuclei but are selectively retained and matured in the nucleus, where they function in pre-rRNA processing. Our results demonstrate that Box D, a conserved sequence element found in these and most other snoRNAs, plays a key role in their nuclear retention, 5' cap hypermethylation and stability. Retention of U3 and U8 RNAs in the nucleus is… CONTINUE READING