A common locus for late-onset Fuchs corneal dystrophy maps to 18q21.2-q21.32.

@article{Sundin2006ACL,
  title={A common locus for late-onset Fuchs corneal dystrophy maps to 18q21.2-q21.32.},
  author={Olof H. Sundin and Karl W. Broman and Howard Y Chang and Elizabeth C L Vito and Walter J. Stark and John D. Gottsch},
  journal={Investigative ophthalmology & visual science},
  year={2006},
  volume={47 9},
  pages={3919-26}
}
PURPOSE To identify the genetic basis of late-onset Fuchs corneal dystrophy (FCD). METHODS Phenotypes and genotypes at 1107 short tandem repeat polymorphism markers were obtained for 43 affected and 33 unaffected individuals in three large families. Two-point genetic linkage analysis was performed with MLINK and multipoint linkage with SimWalk 2.89. RESULTS In each family, the most significant cluster of two-point lod scores mapped to chromosome 18, at 18q21.2-q21.3. The highest two-point… CONTINUE READING
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Statistics in Human Genetics. Arnold: London; 1998;95–97

  • P. Sham
  • Sundin et al. IOVS, September 2006,
  • 2006

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